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Nature Article

New Nature Paper: ecNGS for genomic safety

Read the Nature paper
TwinStrand Biosciences
  • Technology
  • DuplexSeq™ Kits
    • AML Assay
    • Mutagenesis Assay
    • Custom
  • Resources
    • Publications
    • Posters
    • Safety
    • Patents
  • Company
    • Our Team
    • Careers
    • Events
    • News
    • Investors
  • Contact

 

Events

 

JAN 17 @12 PM EST
The future of mutagenesis testing is here
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The future of mutagenesis testing is here
JAN 17 @12 PM EST
The future of mutagenesis testing is here

The coming revolution in mutagenicity testing: application of Duplex Sequencing to quantify and characterize mutations

Learn More
December 10 - 13, 2022
American Society of Hematology (ASH) 64th Annual Meeting & Exposition

Exhibit Hall: Booth #1224
 
If you are attending ASH in person and would like to schedule a time to meet, click here.

LEARN MORE
November 13 - 16, 2022
American College of Toxicology (ACT)

TwinStrand Biosciences is a Gold sponsor at the 43rd Annual Meeting of ACT in Denver, CO and co-hosting Symposium #3 on November 14th – 9am – 12pm
entitled Applications for Duplex Sequencing of DNA in Genetic Toxicology: A Sneak Peek into the Future of Hazard Identification and Risk Assessment.
 
Learn how Duplex Sequencing technology can provide novel mechanistic insights and valuable Weight-of-Evidence for your genetic toxicology studies.

LEARN MORE
October 5 - 7, 2022
German Society for Environmental Mutation Research (GUM)

TwinStrand Biosciences is a proud sponsor of the 33rd annual GUM meeting in Würzburg, Germany

LEARN MORE
September 18 - 21, 2022
The 16th International Congress of Toxicology (ICT XVI)

Uniting in Toxicology
 
TwinStrand Biosciences is a proud sponsor of the 16th International
Congress of Toxicology (ICT)
 
Exhibit Hall: Booth #4A

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August 27 - September 1, 2022
13th International Conference on Environmental Mutagens (ICEM)

Maintaining Genomic Health in a Changing World
TwinStrand Biosciences is a Diamond sponsor at the 13th International Conference on Environmental Mutagens

LEARN MORE
July 31 - August 3, 2022
Cancer Genomics Consortium (CGC) 13th Annual Meeting 2022

TwinStrand Biosciences is a gold sponsor at the 2022 Annual Meeting
Gold Sponsor Industry Showcases: Monday, August 1st at 3:23pm CST
Exhibit Hall: Booth #22

LEARN MORE
July 3 - 6, 2022
UKEMS (United Kingdom Environmental Mutagen Society) 2022 Annual Meeting

TwinStrand Biosciences will be the gold sponsor at the 2022 Annual Meeting at the Royal Hall in Harrogate

REGISTRATION INFO
June 6 - 9, 2022
AGBT: Advances in Genome Biology and Technology General Meeting
CONFERENCE INFO
May 12, 2022
Next Generation Sequencing Workshop

TwinStrand Biosciences, in collaboration with the UKEMS (United Kingdom Environmental Mutagen Society), is hosting a Next Generation Sequencing Workshop on Thursday, May 12th at 1 Wimpole Street, London.
 

Registration Info
May 4-7, 2022
ISCT 2022

Poster Presentation by Zach Norgaard
Thursday, May 5th, 2022 – 5:45pm – 7:15pm PST

Ultra-Sensitive Duplex Sequencing for Quantifying Multi-Individual Cell Therapy Sub-Population Fractions

LEARN MORE
April 20-21, 2022
Life Science Innovation Northwest 2022

CEO Jesse Salk MD, PhD will be speaking at the Life Sciences Innovation Northwest (LSINW) 2022 Convention during the Research Tools & Medical Device session.
 
Wednesday, April 20th, 2022 – 2:46pm PST

LEARN MORE
April 8-13, 2022
AACR Annual Meeting 2022

 
Poster Presentation by Jake Higgins, PhD
Monday, April 11th, 2022 – 9:00am – 12:30pm CDT
Duplex Sequencing reveals ubiquitous clonal hematopoiesis and complex
donor-recipient clonal dynamics following hematopoietic stem cell transplant

Conference Info
March 1-3, 2021
Advances in Genome Biology and Technology (AGBT 2021 Virtual)

 

Bronze Sponsorship Talk presented by CEO Jesse Salk, MD, PhD
Wednesday, March 3, 2021 – 2:45pm – 3:00pm EST
Ultra-Sensitive Duplex Sequencing for Tracking of Allogeneic Cell Therapies

Conference Info
December 5 - 8, 2020
American Society of Hematology (ASH 2020 Virtual)

 

Poster Presentation by Jake Higgins, PhD
December 6, 2020 – 7:00 am – 3:30 pm PST
Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia

Conference Info
November 30, 2020
UK Industrial Genotoxicity Group (IGG) 2020 Virtual Meeting

 

Webinar Presentation by CEO Jesse Salk, MD, PhD
November 30, 2020 – 2:00 pm GMT (6:00 am PST)

Conference Info
October 1 - 4, 2020
22nd Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy

 

Presentation by Jake Higgins, PhD
Rapid, High Precision Identification of Relative Sensitivity of Different Resistance Mutations to TKI Therapies using In Vitro Competition and Ultra-Accurate Duplex Sequencing

Conference Info
September 12 - 16, 2020
Environmental Mutagenesis & Genomics Society (EMGS) Meeting

Presentations and Posters featuring TwinStrand Duplex Sequencing™ Technology

  • Adapting Next-Generation Genetic Toxicology Endpoints to the Human In Vitro Air-Liquid-Interface Airway Tissue Model, Yiying Wang, FDA/NCTR
  • Adopting Duplex Sequencing Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)- Exposed Rats, Stephanie Smith-Roe, National Toxicology Program
  • Comparison of Duplex Sequencing and CarcSeq Error-Corrected NGS methods for Detection of Preneoplastic Clonal Expansions in Normal, Healthy Human Tissues, Meagan Myers, PhD, DHHS/FDA/NCTR
  • Duplex Sequencing™ Demonstrates Dose-related Increases in Mutation Frequencies and C>A Transitions in the Bone Marrow of MutaMouse Males Exposed to Benzo(a)pyrene. LeBlanc, D. et al.
  • Error-Corrected Duplex Sequencing; Bioinformatic Challenges, Clint Valentine, TwinStrand
  • Extension of Error-Corrected Duplex Sequencing to Structural Variant Detection, Thomas E. Wilson, MD, PhD, University of Michigan Medical School
  • Interspecies Comparison of Chemical-induced Mutagenesis by Duplex Sequencing, Bob Young, Millipore-Sigma
  • Ultra-Deep Sequencing of Blood and Urine to Test for Exposure to Aristolochic Acids, Arnoud Boot, Duke-NUS Medical School
Conference Info
July 16 - 17, 2020
Life Science Innovation Northwest 2020

 

Virtual Presentation by CEO Jesse Salk, MD, PhD
“Ultrasensitive Genetic Detection: Below One-In-One-Million”

 

TwinStrand is a science-first genomics company based around Duplex Sequencing, an ultra-sensitive DNA analysis technology designed to improve cancer diagnostics. We use a combination of specialized biochemistry and powerful cloud-based computation to improve the accuracy of existing DNA sequencers by more than 10,000-fold. This unprecedented resolution lets us solve a variety of clinically actionable oncologic ‘needle in a haystack’ problems such as early detection of cancer, monitoring for residual tumor cells after therapy and identification of new chemicals and environmental exposures that put people at risk for cancer. We make it possible for researchers to see faint signals that were previously hidden, to help our collective effort to reduce global burden of cancer.

Conference Info
February 23 - 26, 2020
AGBT Advances in Genome Biology and Technology

 
Presentation by CEO Jesse Salk, MD, PhD
Ultra-Sensitive Residual Leukemia Detection with Patient-Specific Duplex Sequencing

 

View Talk

 

Poster Presented
Super CHIP: Duplex Sequencing Reveals Clonal Dynamics in Blood that are Magnitudes more Complex than Previously Recognized

 

View Poster

Conference Info
January 21 - 24, 2020
Precision Medicine World Wide Conference (PMWC)

 

Presentation by CEO Jesse Salk, MD, PhD
Ultrasensitive Minimal Residual Disease Detection By Duplex Sequencing

 

Abstract
Duplex Sequencing enables an unprecedented level of NGS accuracy, with error rates below one-in-ten-million. The technology is ideally suited to detection of residual cancer (MRD), where lingering tumor cells are vastly outnumbered by normal cells. Here we present Duplex Sequencing-based MRD data from three clinical studies in acute myeloid leukemia.

Conference Info
January 13 - 16, 2020
AACR: Advances in Liquid Biopsies

 

Presentation by Jake Higgins
Clonal Landscapes of Hematologic Malignancies Redefined by Ultra-Sensitive Duplex Sequencing

 

View Poster Presented at Event

Conference Info
December 7 - 10, 2019
American Society of Hematology (ASH)

 

Conference Info
June 22 - 24, 2019
AACR Environmental Carcinogenesis

 

Presentation by CEO Jesse Salk, MD, PhD
Genetic susceptibility and biologic markers of carcinogen exposure

Conference Info
March 29 - April 3, 2019
AACR Annual Meeting

 

View Posters Presented at Event

Conference Info
March 10 - March 14, 2019
Society of Toxicology (SOT)

 

View Poster Presented at Event

Conference Info

 

TwinStrand Biosciences, Inc.
3131 Elliott Ave, Suite 750 • Seattle, WA 98121 • USA
+1 (877) 202-TWIN

 

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American Society of Hematology (ASH)

December 5-8, 2020 – Virtual

 

Poster Presentation

 

“Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia”

 

Presented by Jake Higgins, Senior Scientist – December 6, 2020 7:00 a.m.-3:30 p.m. PST

 

Conference Website

 

Society of Toxicology (SOT)

March 10-14, 2019 – Baltimore, MD

 

Poster Presentations

 

 

View Poster

 

 

Conference Website

 

AACR Annual Meeting – San Diego, CA

March 29-April 3, 2019

 

Poster Presentations

 

 

View Poster

 

 

View Poster

Presentations by CEO Jesse Salk, MD, PhD – AGBT 2020

Ultra-Sensitive Residual Leukemia Detection with Patient-Specific Dupex Sequencing