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TwinStrand DuplexSeq measuring MRD in AML

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RETHINK GENETIC TOXICOLOGY

Characterize mutations in vitro and in vivo with DuplexSeqTM Mutagenesis Assays

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LEARN MORE ABOUT OUR TECHNOLOGY

Standard mutagenesis assays have significant limitations

AMES Test
in vitro

Mammalian Cell Gene Mutation
Assays (TK, MLA, HPRT)
in vitro

Transgenic Rodent (TGR) Assay
in vivo

Pig-a Assay
in vivo

DuplexSeqTM Mutagenesis Assays
in vitro + in vivo
Compatible with wild-type rodents x-mark x-mark x-mark checkmark checkmark
Compatible with all standard tissue types x-mark x-mark checkmark x-mark checkmark
Compatible with in vitro model systems checkmark checkmark x-mark x-mark checkmark
Can identify the specific mutations induced x-mark x-mark x-mark x-mark checkmark
Provides information about mutagenic mechanism checkmark x-mark x-mark x-mark checkmark

Standard mutagenesis assays have significant limitations

AMES Test
in vitro

  • Compatible with wild-type rodents
  • Compatible with all standard tissue types
  • Compatible with in vitro model systems
  • Can identify the specific mutations induced
  • Provides information about mutagenic mechanism

Mammalian Cell Gene Mutation
Assays (TK, MLA, HPRT)
in vitro

  • Compatible with wild-type rodents
  • Compatible with all standard tissue types
  • Compatible with in vitro model systems
  • Can identify the specific mutations induced
  • Provides information about mutagenic mechanism

Transgenic Rodent (TGR) Assay
in vitro

  • Compatible with wild-type rodents
  • Compatible with all standard tissue types
  • Compatible with in vitro model systems
  • Can identify the specific mutations induced
  • Provides information about mutagenic mechanism

Pig-a Assay
in vivo

  • Compatible with wild-type rodents
  • Compatible with all standard tissue types
  • Compatible with in vitro model systems
  • Can identify the specific mutations induced
  • Provides information about mutagenic mechanism

DuplexSeqTM Mutagenesis Assays
in vitro OR in vivo

  • Compatible with wild-type rodents
  • Compatible with all standard tissue types
  • Compatible with in vitro model systems
  • Can identify the specific mutations induced
  • Provides information about mutagenic mechanism

Overcome the limitations of conventional mutagenesis assays by characterizing DNA mutations in vitro or in vivo from a wide array of samples

TwinStrand’s DuplexSeqTM Mutagenesis Assays use error-corrected NGS (ecNGS) technology to characterize DNA mutations and calculate mutational frequencies.

Flexible

  • Compatible with in vivo and in vitro studies
  • Kits for human, mouse, and rat samples
  • Compatible with any cell type and tissue

Comprehensive

  • Directly detect and quantify mutation frequency
  • Characterize mutation spectra and signatures
  • Gain insight into mutagenic mechanisms

Powerful

  • Eliminates the need for transgenic rodent models
  • Streamline nitrosamine impurities testing
  • Consistent, repeatable readouts across sample types

Detailed product information can be found in our data sheet.

DOWNLOAD DATA SHEET
DOWNLOAD DATA SHEET

Streamlined, end-to-end solution for sample analysis

DuplexSeqTM Mutagenesis Assays include both the sample preparation kit and software that automatically analyzes your data and generates an easy-to-read report. This simple system is easily added to any genetic toxicology program—without the need for bioinformatics expertise.

Sample
Preparation

Sequencing

Mutation
Analysis

DOWNLOAD SAMPLE REPORT
Download Sample Report

Ordering information

Kit Type Product Name Number of Reactions Product Number
Human TwinStrand Duplex Sequencing® Mutagenesis Panel (Human-50), v1.0 24 06-1005-02
48 06-1005-03
Mouse TwinStrand Duplex Sequencing® Mutagenesis Panel (Mouse-50), v1.0 24 06-1006-02
48 06-1006-03
Rat TwinStrand Duplex Sequencing® Mutagenesis Panel (Rat-50), v1.0 24 06-1007-02
48 06-1007-03
Request a quote
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Resources

We’ve published with our collaborators a significant amount of data in prestigious, peer-reviewed journals that demonstrate the benefits of Duplex Sequencing in genetic toxicology.

VIEW PUBLICATIONS
View Publications

HESI position publication

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Webinar

The coming revolution in mutagenicity testing: Application of Duplex Sequencing to quantify and characterize mutations

For Research Use Only. Not for use in diagnostic procedures.

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