It’s a simple but revolutionary idea—overcome the limitations of standard sequencing by independently tracking both strands of individual DNA molecules and comparing the results to eliminate errors.
Using a combination of proprietary biochemistry and cloud-based informatics, Duplex Sequencing greatly increases the resolution of next generation sequencing by reducing error rates from about 1-in-100 to 1-in-10 million.
Now even the rarest variants can be detected with unparalleled sensitivity and unprecedented specificity.
A complete solution
TwinStrand Duplex Sequencing technology is an end-to-end solution, from pre-sequencing biochemistry to post-sequencing bioinformatics. Using standard sequencing systems and an easy-to-adopt workflow, errors are reduced to below one artifactual mutation per ten million nucleotides.
Imagine the possibilities
Duplex Sequencing can inform critical decisions in clinical medicine, public health, and other fields of science—on a faster time scale, where actions are most impactful.
Cancers can be detected and treated sooner. Drug resistance can be identified earlier. Residual diseases can be confirmed quickly. Mutagenetic chemicals can be recognized faster.
