Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias
Targeted Genome Fragmentation with CRISPR/Cas9 Enables Fast and Efficient Enrichment of Small Genomic Regions and Ultra-Accurate Sequencing with Low DNA Input (CRISPR-DS)
Enhancing the Accuracy of Next-Generation Sequencing for Detecting Rare and Subclonal Mutations
Next-generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of ∼1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but […]
