TwinStrand DuplexSeq measuring MRD in AML

Detection of Ultra-Rare Mutations by Next-Generation Sequencing

Mutations, the fuel of evolution, are first manifested as rare DNA changes within a population of cells. Although next-generation sequencing (NGS) technologies have revolutionized the study of genomic variation between species and individual organisms, most have limited ability to accurately detect and quantify rare variants among the different genome copies in heterogeneous mixtures of cells […]