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TwinStrand DuplexSeq measuring MRD in AML

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Longitudinal monitoring of pediatric acute myeloid leukemia using duplex sequencing of patient-specific panels reveals ultra-low frequency MRD that marks persistent carcinogenesis and complex clonal evolution

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Danielle LeBlanc is a Biologist at Health Canada under the supervision of Dr. Francesco Marchetti. Danielle completed her undergraduate and Masters work at Carleton University in Ottawa. Danielle is currently focusing on the implementation of Duplex Sequencing for in vivo mutagenesis assessment at Health Canada.

In her spare time, she loves to cross-country ski, bake cupcakes and craft cocktails.

Dr. Francesco Marchetti is a Senior Research Scientist at Health Canada and Adjunct Research Professor at Carleton University. He chairs the Germ Cell workgroup of the Health and Environmental Science Institute’s Genetic Toxicology Technical Committee and is a member of the Organisation for the Economic Co-Operation and Development Expert Group on Genotoxicity Testing. Dr. Marchetti has authored over 125 peer-reviewed publications.

He was Editor-In-Chief of Environmental and Molecular Mutagenesis (EMM) during 2012-2016 and serves on the editorial boards of EMM and Mutagenesis. Dr. Marchetti is the current President of the Environmental Mutagenesis and Genomic Society.