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TwinStrand DuplexSeq measuring MRD in AML

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NITROSAMINE MUTAGENICITY TESTING

Duplex Sequencing offers a solution for those in need of in vivo mutagenicity data

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TwinStrand DuplexSeqTM for assessing nitrosamine impurities

Don’t wait for your in vivo mutagenicity data

Duplex Sequencing studies provide the Mutation Frequency (MF) data you need for mutagenicity testing and BMD modeling without having to wait for a TGR study.

  • Compatible with both wild-type and transgenic rodents
  • Repurpose tissues from general tox studies to assess mutagenicity
  • Gain additional data on mutation type to supplement mutation frequency

Resources

Duplex Sequencing has been successfully applied to nitrosamine testing. The Bercu et al. paper provides an excellent template for nitrosamine studies using ecNGS. The HESI position paper offers expert perspective on applications for ecNGS in nonclinical genotoxicity testing. More publications featuring nitrosamine and bridging studies can be found on the publications page.

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NITROSAMINE (NDEA) PUBLICATION ​

Comparative dose-response study assessing the detection of N-nitrosamine (NDEA) exposure using ecNGS (Duplex Sequencing) and the TGR Assay​

HESI position publication

A position paper on genetic toxicology applications for ecNGS written by members of the HESI Genetic Toxicology Technical Committee (GTTC) – an interdisciplinary group of genetox experts from industry, academia, and government ​

For Research Use Only. Not for use in diagnostic procedures.

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